A new series of N-mannich bases of benzothiazolone derived from 2-amino-5-aryl-1,3,4-thiadiazoles were characterized and evaluated for antimicrobial activities. The synthesized 2-oxobenzothiazoline used to prepare N-Mannich bases with 2-amino-5-aryl-1,3,4-thiadiazoles. The resulting compounds after purification and identification by spectral data were tested for antimicrobial activities. Compounds 3d & 3e were found to possess significant antibacterial activity against both gram positive and gram negative bacteria at the tested concentrations when compared with that of standard drug ampicillin. In antifungal study, compounds 3b, 3d and 3e have exhibited significant anti fungal activity when compared with standard drug fluconazole. The synthesized compounds can be further exploited to get the potent lead compounds.
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